2024

• Designing, Developing, and Testing a Chatbot for Parents and Caregivers of Children and Young People With Rheumatological Conditions (the IMPACT Study): Protocol for a Co-Designed Proof-of-Concept Study.
  Livermore P, Kupiec K, Wedderburn LR, Knight A, Solebo AL, Shafran R, Robert G, Sebire NJ, Gibson F; IMPACT Steering Group.
  JMIR Res Protoc. 2024 Apr 3;13:e57238. doi: 10.2196/57238. PMID: 38568725
• Economic evaluation of a trial exploring the effects of a web-based support tool for parents of children with juvenile idiopathic arthritis.
  Flood C, Hirani SP, Mulligan K, Taylor J, Harris S, Wedderburn LR, Newman SP.
  Rheumatology (Oxford). 2024 Mar 22:keae188. doi: 10.1093/rheumatology/keae188. Online ahead of print. PMID: 38519117
• Synovial 5-LOX-derived oxylipins define a lympho-myeloid-enriched synovium.
  Murillo-Saich JD, Coras R, Ramirez J, Quesada-Masachs E, Sala-Climent M, Eschelbach K, Mahony CB, Celis R, Armando A, Quehenberger O, Croft AP, Kavanaugh A, Chang E, Cañete JD, Singh A, Guma M.
  Arthritis Rheumatol. 2024 Mar 20. doi: 10.1002/art.42848. Online ahead of print. PMID: 38508862
• All fibroblasts are equal, but some are more equal than others.
  Bolton C, Croft AP.
  Nat Rev Rheumatol. 2024 Mar 11. doi: 10.1038/s41584-024-01097-6. Online ahead of print. PMID: 38467780 No abstract available.
• CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis.
  Rauber S, Mohammadian H, Schmidkonz C, Atzinger A, Soare A, Treutlein C, Kemble S, Mahony CB, Geisthoff M, Angeli MR, Raimondo MG, Xu C, Yang KT, Lu L, Labinsky H, Saad MSA, Gwellem CA, Chang J, Huang K, Kampylafka E, Knitza J, Bilyy R, Distler JHW, Hanlon MM, Fearon U, Veale DJ, Roemer FW, Bäuerle T, Maric HM, Maschauer S, Ekici AB, Buckley CD, Croft AP, Kuwert T, Prante O, Cañete JD, Schett G, Ramming A.
  Nat Immunol. 2024 Apr;25(4):682-692. doi: 10.1038/s41590-024-01774-4. Epub 2024 Feb 23. PMID: 38396288
• Overlap of International League of Associations for Rheumatology and Preliminary Pediatric Rheumatology International Trials Organization Classification Criteria for Nonsystemic Juvenile Idiopathic Arthritis in an Established UK Multicentre Inception Cohort.
  Shoop-Worrall SJW, Macintyre VG, Ciurtin C, Cleary G, McErlane F, Wedderburn LR; Childhood Arthritis Prospective Study (CAPS) Principal Investigators; Hyrich KL.
  Arthritis Care Res (Hoboken). 2024 Jan 11. doi: 10.1002/acr.25296. Online ahead of print. PMID: 38212149
• Towards stratified treatment of JIA: machine learning identifies subtypes in response to methotrexate from four UK cohorts.
  Shoop-Worrall SJW, Lawson-Tovey S, Wedderburn LR, Hyrich KL, Geifman N; CLUSTER Consortium.
  EBioMedicine. 2024 Feb;100:104946. doi: 10.1016/j.ebiom.2023.104946. Epub 2024 Jan 8. PMID: 38194741 Free PMC article.

2023

• Development and implementation of ‘A guide to PPIE – Early Integration into Research Proposals’ in a multi-disciplinary consortium.
  Beesley R, Luling Feilding F; CLUSTER Consortium Champions; Rosser EC, Shoop-Worrall SJW, McNeece A, Wanstall Z, Hyrich K, Wedderburn LR; CLUSTER Consortium.
  Rheumatology (Oxford). 2024 Mar 1;63(3):e88-e91. doi: 10.1093/rheumatology/kead482. PMID: 37707533 Free PMC article. No abstract available.
• Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes.
  Thompson KN, Bonham KS, Ilott NE, Britton GJ, Colmenero P, Bullers SJ, McIver LJ, Ma S, Nguyen LH, Filer A, Brough I, Pearson C, Moussa C, Kumar V, Lam LH, Jackson MA, Pawluk A; Inflammatory Arthritis Microbiome Consortium (IAMC) investigators group; Kiriakidis S, Taylor PC, Wedderburn LR, Marsden B, Young SP, Littman DR, Faith JJ, Pratt AG, Bowness P, Raza K, Powrie F, Huttenhower C; IAMC.
  Sci Transl Med. 2023 Jul 26;15(706):eabn4722. doi: 10.1126/scitranslmed.abn4722. Epub 2023 Jul 26. PMID: 37494472
• The impact of psoriasis on wellbeing and clinical outcomes in juvenile psoriatic arthritis.
  Low JM, Hyrich KL, Ciurtin C, McErlane F, Wedderburn LR; CAPS Principal Investigators.
  Rheumatology (Oxford). 2023 Jul 19:kead370. doi: 10.1093/rheumatology/kead370. Online ahead of print. PMID: 37467079
• The successes and challenges of harmonising juvenile idiopathic arthritis (JIA) datasets to create a large-scale JIA data resource.
  Lawson-Tovey S, Smith SL, Geifman N, Shoop-Worrall S, Ng S, Barnes MR, Wedderburn LR, Hyrich KL; CLUSTER consortium.
  Pediatr Rheumatol Online J. 2023 Jul 13;21(1):70. doi: 10.1186/s12969-023-00839-2. PMID: 37438749 Free PMC article.
• Juvenile idiopathic inflammatory myositis: an update on pathophysiology and clinical care.
  Papadopoulou C, Chew C, Wilkinson MGL, McCann L, Wedderburn LR.
  Nat Rev Rheumatol. 2023 Jun;19(6):343-362. doi: 10.1038/s41584-023-00967-9. Epub 2023 May 15. PMID: 37188756 Free PMC article. Review.
• Are the origins of adult arthritis seeded during embryonic development?
  Hackland A, Croft AP.
  Nat Rev Rheumatol. 2023 Mar;19(3):132-133. doi: 10.1038/s41584-023-00911-x. PMID: 36721051 No abstract available.
• Genomic diagnosis and care co-ordination for monogenic inflammatory bowel disease in children and adults: consensus guideline on behalf of the British Society of Gastroenterology and British Society of Paediatric Gastroenterology, Hepatology and Nutrition.
  Kammermeier J, Lamb CA, Jones KDJ, Anderson CA, Baple EL, Bolton C, Braggins H, Coulter TI, Gilmour KC, Gregory V, Hambleton S, Hartley D, Hawthorne AB, Hearn S, Laurence A, Parkes M, Russell RK, Speight RA, Travis S, Wilson DC, Uhlig HH.
  Lancet Gastroenterol Hepatol. 2023 Mar;8(3):271-286. doi: 10.1016/S2468-1253(22)00337-5. Epub 2023 Jan 9.
  PMID: 36634696 Review.
• Towards molecular-pathology informed clinical trials in childhood arthritis to achieve precision medicine in juvenile idiopathic arthritis.
  Wedderburn LR, Ramanan AV, Croft AP, Hyrich KL, Dick AD; CLUSTER Consortium.
  Ann Rheum Dis. 2023 Apr;82(4):449-456. doi: 10.1136/ard-2022-222553. Epub 2022 Dec 5. PMID: 36600186 Free PMC article. Review.
• Identification of Novel Associations and Localization of Signals in Idiopathic Inflammatory Myopathies Using Genome-Wide Imputation.
  Rothwell S, Amos CI, Miller FW, Rider LG, Lundberg IE, Gregersen PK, Vencovsky J, McHugh N, Limaye V, Selva-O’Callaghan A, Hanna MG, Machado PM, Pachman LM, Reed AM, Molberg Ø, Benveniste O, Mathiesen P, Radstake T, Doria A, De Bleecker JL, De Paepe B, Maurer B, Ollier WE, Padyukov L, O’Hanlon TP, Lee A, Wedderburn LR, Chinoy H, Lamb JA; Myositis Genetics Consortium.
  Arthritis Rheumatol. 2023 Jun;75(6):1021-1027. doi: 10.1002/art.42434. Epub 2023 Mar 20. PMID: 36580032 Free PMC article.
• Role of CD14+ monocyte-derived oxidised mitochondrial DNA in the inflammatory interferon type 1 signature in juvenile dermatomyositis.
  Wilkinson MGL, Moulding D, McDonnell TCR, Orford M, Wincup C, Ting JYJ, Otto GW, Restuadi R, Kelberman D, Papadopoulou C, Castellano S, Eaton S, Deakin CT, Rosser EC, Wedderburn LR.
  Ann Rheum Dis. 2023 May;82(5):658-669. doi: 10.1136/ard-2022-223469. Epub 2022 Dec 23. PMID: 36564154 Free PMC article.
• Cytokine production by human B cells: role in health and autoimmune disease.
  de Gruijter NM, Jebson B, Rosser EC.
  Clin Exp Immunol. 2022 Dec 31;210(3):253-262. doi: 10.1093/cei/uxac090. PMID: 36179248 Free PMC article. Review.
• Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases.
  Korsunsky I, Wei K, Pohin M, Kim EY, Barone F, Major T, Taylor E, Ravindran R, Kemble S, Watts GFM, Jonsson AH, Jeong Y, Athar H, Windell D, Kang JB, Friedrich M, Turner J, Nayar S, Fisher BA, Raza K, Marshall JL, Croft AP, Tamura T, Sholl LM, Vivero M, Rosas IO, Bowman SJ, Coles M, Frei AP, Lassen K, Filer A, Powrie F, Buckley CD, Brenner MB, Raychaudhuri S.
  Med. 2022 Jul 8;3(7):481-518.e14. doi: 10.1016/j.medj.2022.05.002. Epub 2022 May 31. PMID: 35649411 Free PMC article.
• The Effects of a Web-Based Tool for Parents of Children With Juvenile Idiopathic Arthritis: Randomized Controlled Trial.
  Mulligan K, Hirani SP, Harris S, Taylor J, Wedderburn LR, Newman S; WebParC Investigator group.
  J Med Internet Res. 2022 May 12;24(5):e29787. doi: 10.2196/29787.
  PMID: 35551065 Free PMC article. Clinical Trial.
• Use of MRP8/14 in clinical practice as a predictor of outcome after methotrexate withdrawal in patients with juvenile idiopathic arthritis.
  Sumner EJ, Almeida B, Palman J, Bale P, Heard C, Holzinger D, Roth J, Foell D, Robinson E, Ursu S, Wallace C, Gilmour K, Wedderburn LR, Ralph E.
  Clin Rheumatol. 2022 Sep;41(9):2825-2830. doi: 10.1007/s10067-022-06165-4. Epub 2022 Apr 29. PMID: 35486225 Free PMC article.
• Fibroblasts, a target for imaging and therapeutics in rheumatoid arthritis.
  Carvajal Alegria G, Croft AP.
  Rheumatology (Oxford). 2022 Jul 6;61(7):2726-2727. doi: 10.1093/rheumatology/keab845. PMID: 34791115 No abstract available.
• 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care – Preliminary Report.
  100,000 Genomes Project Pilot Investigators; Smedley D, Smith KR, Martin A, Thomas EA, McDonagh EM, Cipriani V, Ellingford JM, Arno G, Tucci A, Vandrovcova J, Chan G, Williams HJ, Ratnaike T, Wei W, Stirrups K, Ibanez K, Moutsianas L, Wielscher M, Need A, Barnes MR, Vestito L, Buchanan J, Wordsworth S, Ashford S, Rehmström K, Li E, Fuller G, Twiss P, Spasic-Boskovic O, Halsall S, Floto RA, Poole K, Wagner A, Mehta SG, Gurnell M, Burrows N, James R, Penkett C, Dewhurst E, Gräf S, Mapeta R, Kasanicki M, Haworth A, Savage H, Babcock M, Reese MG, Bale M, Baple E, Boustred C, Brittain H, de Burca A, Bleda M, Devereau A, Halai D, Haraldsdottir E, Hyder Z, Kasperaviciute D, Patch C, Polychronopoulos D, Matchan A, Sultana R, Ryten M, Tavares ALT, Tregidgo C, Turnbull C, Welland M, Wood S, Snow C, Williams E, Leigh S, Foulger RE, Daugherty LC, Niblock O, Leong IUS, Wright CF, Davies J, Crichton C, Welch J, Woods K, Abulhoul L, Aurora P, Bockenhauer D, Broomfield A, Cleary MA, Lam T, Dattani M, Footitt E, Ganesan V, Grunewald S, Compeyrot-Lacassagne S, Muntoni F, Pilkington C, Quinlivan R, Thapar N, Wallis C, Wedderburn LR, Worth A, Bueser T, Compton C, Deshpande C, Fassihi H, Haque E, Izatt L, Josifova D, Mohammed S, Robert L, Rose S, Ruddy D, Sarkany R, Say G, Shaw AC, Wolejko A, Habib B, Burns G, Hunter S, Grocock RJ, Humphray SJ, Robinson PN, Haendel M, Simpson MA, Banka S, Clayton-Smith J, Douzgou S, Hall G, Thomas HB, O’Keefe RT, Michaelides M, Moore AT, Malka S, Pontikos N, Browning AC, Straub V, Gorman GS, Horvath R, Quinton R, Schaefer AM, Yu-Wai-Man P, Turnbull DM, McFarland R, Taylor RW, O’Connor E, Yip J, Newland K, Morris HR, Polke J, Wood NW, Campbell C, Camps C, Gibson K, Koelling N, Lester T, Németh AH, Palles C, Patel S, Roy NBA, Sen A, Taylor J, Cacheiro P, Jacobsen JO, Seaby EG, Davison V, Chitty L, Douglas A, Naresh K, McMullan D, Ellard S, Temple IK, Mumford AD, Wilson G, Beales P, Bitner-Glindzicz M, Black G, Bradley JR, Brennan P, Burn J, Chinnery PF, Elliott P, Flinter F, Houlden H, Irving M, Newman W, Rahman S, Sayer JA, Taylor JC, Webster AR, Wilkie AOM, Ouwehand WH, Raymond FL, Chisholm J, Hill S, Bentley D, Scott RH, Fowler T, Rendon A, Caulfield M.
  N Engl J Med. 2021 Nov 11;385(20):1868-1880. doi: 10.1056/NEJMoa2035790. PMID: 34758253 Free PMC article..
• Critical Role of Synovial Tissue-Resident Macrophage and Fibroblast Subsets in the Persistence of Joint Inflammation.
  Kemble S, Croft AP. Front Immunol. 2021 Sep 3;12:715894. doi: 10.3389/fimmu.2021.715894. eCollection 2021. PMID: 34539648 Free PMC article. Review.
• Fibroblast pathology in inflammatory joint disease.
  Marsh LJ, Kemble S, Reis Nisa P, Singh R, Croft AP.
  Immunol Rev. 2021 Jul;302(1):163-183. doi: 10.1111/imr.12986. Epub 2021 Jun 6. PMID: 34096076 Review.